At this moment of time, there's not gonna be much difference since there's kinda no players, but for example in situation like;
My character is a black guy that lives in Davis, and around a week ago I shot a member of an enemy gang. My character does the delivery job as it's easy to do, delivering to places around Davis before 2 guys jumped out of their vehicles in front of me while I was stepping out the delivery truck, spraying bullets at myself, so I run to the trunk, and.... I did the pickup crate animation, and died.
It's just always better to do it manually.